How does AMD damage vision?
What are the symptoms of AMD?
How is AMD treated?
Who is at risk for AMD?
How is AMD detected?
How is laser surgery performed?

Age-related macular degeneration (AMD) is a disease that affects your central vision. It is a common cause of vision loss among people over age of 60.

Because only the center of your vision is usually affected, people rarely go blind from the disease. However, AMD can sometimes make it difficult to read, drive, or perform other daily activities that require fine, central vision.

How does AMD damage vision?
AMD occurs in two forms:
Dry AMD affects about 90 percent of those with the disease. Its cause is unknown. Slowly, the light sensitive cells in the macula break down. With less of the macula working, you may start to lose central vision in the affected eye as the years go by. Dry AMD often occurs in just one eye at first. You may get the disease later in the other eye. Doctors have no way of knowing if or when both eyes may be affected.


Dry and Wet
Macular Degeneration

Wet AMD—Although only 10 percent of all people with AMD have this type, it accounts for 90 percent of all blindness from the disease. It occurs when new blood vessels behind the retina start to grow toward the macula. Because these new blood vessels tend to be very fragile, they will often leak blood and fluid under the macula. This causes rapid damage to the macula that can lead to the loss of central vision in a short period of time.

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Who is at risk for AMD?

Although AMD can occur during middle age, the risk increases as a person gets older. Results of a large study show that people in their 50s have about a 2 percent chance of getting AMD. This risk rises to nearly 30 percent in those over age 75. Besides age, other AMD risk factors include:

Gender—Women may be at greater risk than men, according to some studies.
Smoking—Smoking may increase the risk of AMD.
Family History—People with a family history of AMD may be at higher risk of getting the disease.
Cholesterol—People with elevated levels of blood cholesterol may be at higher risk for wet AMD.

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What are the symptoms of AMD?

Neither dry nor wet AMD causes any pain. The most common symptom of dry AMD is slightly blurred vision. You may need more light for reading and other tasks. Also, you may find it hard to recognize faces until you are very close to them. As dry AMD gets worse, you may see a blurred spot in the center of your vision. This spot occurs because a group of cells in the macula have stopped working. Over time, the blurred spot may get bigger and denser, taking more of your central vision.

People with dry AMD in one eye often do not notice any changes in their vision. With one eye seeing clearly, they can still drive, read, and see fine details. Some people may notice changes in their vision only if AMD affects both of their eyes.

An early symptom of wet AMD is that straight lines appear wavy. This happens because the newly formed blood vessels leak fluid under the macula. The fluid raises the macula from its normal place at the back of the eye and distorts your vision. Another sign that you may have wet AMD is rapid loss of your central vision. This is different from dry AMD in which loss of central vision occurs slowly. As in dry AMD, you may also notice a blind spot.


Normal vision


The same scene as it might be viewed by a person with AMD.
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How is AMD detected?

Eye care professionals detect AMD during an eye examination that includes:
Visual acuity test: This eye chart test measures how well you see at various distances.
Pupil dilation: This examination enables your eye care professional to see more of the retina and look for signs of AMD. To do this, drops are placed into the eye to dilate (widen) the pupil. After the examination, your vision may remain blurred for several hours.
Tonometry: This is a standard test that determines the fluid pressure inside the eye. Increased pressure is a possible sign of glaucoma, another common eye problem in people over age 60.

One of the most common early signs of AMD is the presence of drusen.

Drusen are tiny yellow deposits in the retina. Your eye care professional can see them during an eye examination.

 

The presence of drusen alone does not indicate a disease, but it might mean that the eye is at risk for developing more severe AMD.

While conducting the examination, your eye care professional may ask you to look at an Amsler grid.

This grid is a pattern that resembles a checkerboard. You will be asked to cover one eye and stare at a black dot in the center of the grid. While staring at the dot, you may notice that the straight lines in the pattern appear wavy to you. This may be a sign of wet AMD. (See Amsler Grid below.)

If your eye care professional suspects you have wet AMD, you may need to have a test called
fluorescein angiography.

In this test, a special dye is injected into a vein in your arm. Pictures are then taken as the dye passes through the blood vessels in the retina.

The photos help your eye care professional evaluate leaking blood vessels to determine whether they can be treated.

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How is AMD treated?

Vitamins and minerals. Many researchers and eyecare practitioners believe that antioxidant vitamins, such as beta-carotene (vitamin A) and vitamins C and E, may protect the macula from damage.

In fact, a recently published study of over 3600 people found that supplementation with vitamins C and E, beta-carotene and zinc reduced certain patients' risk of progressing to advanced AMD by about 28%. This number reflects those patients with a lot of intermediate or large drusen, but not those with limited intermediate drusen or multiple small drusen.

Because of their findings, the researchers recommend that patients at risk of developing advanced AMD consider taking antioxidant and zinc supplements. Participants received:

Top: An eye with dry ARMD showed soft drusen (yellow spots), which created blind spots in the patient's vision and severely decreased visual acuity. Bottom: Nine months after laser photocoagulation, the drusen almost disappeared and visual acuity was 20/20. 
 

  • 500 milligrams (mg) of vitamin C
  • 400 international units (IU) of vitamin E
  • 15 mg of beta-carotene
  • and 80 mg of zinc oxide

Bausch & Lomb is now marketing these nutrients in one supplement, called Ocuvite PreserVision.

Note that smokers should avoid beta carotene supplements, as they increase the risk of lung cancer in smokers and those who've recently quit.*

The eyecare community does not agree on the benefits of zinc or antioxidant supplements: more study is needed, especially on the long-term effects of high-dose supplementation. Keep in mind also that too much of any vitamin or mineral may affect the body's ability to absorb other important nutrients.

Visudyne drug treatment. For those with wet AMD, the Food and Drug Administration has recently approved Visudyne, the first-ever drug therapy for this form of the disease. It's only for those whose new blood vessels are characterized as "predominantly classic": about 40% to 60% of new wet AMD patients, according to Visudyne maker CIBA Vision.

In this treatment procedure, the doctor injects Visudyne into your arm, then activates the drug by shining a laser into your eye. In clinical trials, 67% of patients found that either their vision loss stabilized or that their vision improved.

 

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How is laser surgery performed?

Laser treatment. Laser photocoagulation may help wet AMD patients by destroying new blood vessels to prevent leakage. Scientists are currently studying laser treatments for dry AMD as well.

Low vision devices for vision loss. Although much progress has been made recently in ARMD treatment research, as things stand now, any central vision lost to dry AMD will probably not be restored. Your eyecare practitioner may ask you to check your vision with an Amsler grid, a piece of paper with a black grid of lines. Viewing the Amsler grid separately with each eye helps you monitor your vision loss.

For those who have suffered vision loss, many low vision devices are available to help improve vision by using magnifying lenses and bright lights. Some low vision aids shift images to the periphery for clearer vision. 

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