The advantage of the IVI technique is the ability to maximize intraocular levels of medications and to avoid the toxicities associated with systemic treatment.

Indication:

1 - Proliferative Diabetic Retinopathy.
2 - Age Related Macular Degeneration (AMD).
3 - Refractory Macular Edema.

Other conditions can benefit from IVI after careful discussion with your doctor.

The label explains that Avastin™ works by blocking a substance known as vascular endothelial growth factor or VEGF. Blocking or inhibiting VEGF helps prevent further growth of the blood vessels.

Types & Popularity:
 
Since 2000 and 2005, the intravitreal applications of triamcinolone acetonide and bevacizumab/ranibizumab have markedly increased in frequency as therapy of diabetic macular oedema, exudative age-related macular degeneration and other intraocular neovascular or oedematous diseases .

Bevacizumab is commercially known as Avastin™, Rabibizumab is known as Lucentis™.


Complications:

the list of reported complications includes infectious and noninfectious endophthalmitis, secondary ocular hypertension potentially leading to secondary steroid-induced open-angle glaucoma, and iatrogenic lesions to the intraocular structures.